GenaViVe Peptide Botox Alternative

GenaVive Topical Peptide Wrinkle-remover and Age-reversing Peptide Serum by SkinSurrection is our new powerful Botox alternative.   Our peptide serum is a scientifically based formulation which combines the power of multiple bioactive peptides, which have been shown to improve the appearance of wrinkles and fine lines in a manner that is reminiscent of Botox injection.  Other components of our peptide serum improve fine lines and aging changes that are typically addressed by Dermal Fillers using Juvaderm, Restylane.  Instead of filling volume deficiencies in the face with Hyaluronic acid fillers, the peptide complex in GenaViVe works by increasing your own collagen synthesis.  This way, the tissue formed is completely your own.

The Bioactive Peptide Complex. 

The discovery of small peptides with biologically activity happened in the 1970s, when small 3 linked amino-acid peptide fragments produced from hydrolysis (chemical breakdown) of collage molecules (containing sequences of 1000 or more amino-acid units) were shown to have biological effects.  The small fragments were shown to be able to regulate or provide control on the cell types which produce collagen.  In the first case, the fragment, produced by collagen breakdown, stimulated the collagen producing cells to synthesize more collagen. Intuitively, it makes sense that when collagen is being lost or broken down in the matrix cell would result in a signal the cell could recognize to replenish that which was lost.  This helps maintain a balance and homeostasis.

In the decades which followed, more small peptides derived from broken down proteins, were demonstrated to have bioactive effects.  And a number of them were shown to influence nerve and muscle signal transmission.  A number of these were shown to interfere with or block the release of Acetylcholine, a neurotransmitter released by the nerve ending at the site of the muscle’s neuromuscular endplate that facilitates contraction.  Botox and its homologues do just that.  The result is to relax the muscles, like the ones whose excessive tension balance leads to wrinkles.

How Botox works at the junction of the nerve and muscle cell to prevent dynamic wrinkles.
How Botox works at the junction of the nerve and muscle cell to prevent dynamic wrinkles.


Bioactive peptides were quickly adapted for use in cosmetics, although research and improvement in technology occurring over time were necessary to make them more easily available.  Now, there are several products on the market which use peptides.  GHK-Cu, Argireline, Leuphasyl, Vialox, Matrixyl and Matrixyl 3000 are examples of brand name formulations which employ peptides and peptide science.  They represent small peptides, some with chemical modification that include one or more of the following: Tripeptide-3, Acetylhexapeptide-3, Acetylhexapeptide-8, palmitoyl pentapeptide-18, etc.  GenaViVe Peptide Serum Botox Alternative reflects a unique combination of the best bioactive peptide combinations to provide the best possible result.

Chemical Structure of Selective Bioactive peptides. GenaViVe Peptide Serum Botox Alternative by Skinsurrection
Chemical Structure of Selective Bioactive peptides. GenaViVe Peptide Serum Botox Alternative


Advantages of Bioactive Peptides in Cosmetics and Aging Skin

The advantage of using a topical peptide serum is that no injections are needed to get the more youthful appearing skin that is desired.  The potential complications of injections are completely avoided.  And because Botox, Dysport, Xeomin & Jeuveau are subtypes of the potent and dangerous neurotoxins found in the spore-forming bacterium Clostridium botulinum.  Clostridium is a family of organisms which produces tetanus, the toxin responsible for lockjaw and breathing paralysis when exposed to the contents of a sealed can goods where the organism has incubated over time.  Or stepping on a rusty nail.  Most children receive tetanus vaccine boosters to prevent us from being sickened by exposure to this toxin.  Although Botox and other related wrinkle relaxers are generally safe, unfortunate complications that can range from cosmetically unacceptable “eye droop” or facial asymmetry to catastrophic and life-threatening complications that require life support and mechanical ventilation do happen rarely.  Because GenaViVe peptides are short segments, they do not involve these risks. And as a bonus, GenaViVe is a much cheaper alternative to Botox and Filler, costing a fraction of the cost of Botox or filler treatment.   And because it is topical, it is completely safe and painless.  GenaViVe Peptide Serum Botox Alternative is far less expensive than laser procedures (Fraxel, Pixel skin resurfacing), and there is no downtime.

Cost, Duration of Action, Comfort and Safety are GeneViVe’s Big Benefits

Our hope was that for regular Botox and filler users, a topical peptide like GenaViVe Peptide Serum Botox Alternative  may increase the time between injections in addition to enhancing the results of those injection treatments.  Typically, Botox, Dysport, Jeuveau and Xeomin, the most popular Dermal Fillers, last for 4-6 months.  The cost of botulinum toxin may range between $9- $25 per unit.   The total cost of treating wrinkles for the face may range from 25-40 units to treat crow’s feet or 11-lines, but close to 100Units maybe required for the most complex aging face.  Spending $300- $600 for Botox is average, according to data from the American Society of Plastic Surgeons.  However, dedicated Botox users may spend a thousand or more each year to maintain the results.  Filler pricing also varies depending on where you live.  You may spend $500 to $2500 for a single 5 cc syringe of Filler, according to this recent Cosmopolitan Magazine article. And the actual cost will depend not only on the number of syringes, but what type or brand of filler you require and whether it is temporary (Juvederm, Restylane), semi-permanent or permanent (Radiesse, Sculptra).  Although Filler may last 12- 18 months, and residue may last longer than that, 5cc syringes do not cover a lot of volume.  It may suffice for lip enhancement, smile lines, marionette lines, but a single syringe won’t be able to fix all of those together or volumize the deficiency in an aging (sunken) midface.  It costs much more than $1000 for the average face with multiple aging or cosmetic issues.

To be frank, $39.99 is SO MUCH CHEAPER than $1000, especially in today’s economy!


Putting GenaViVe Peptide Botox Alternative to the Test

After formulation the peptide complex in GenaViVe, we asked our existing clients who have aging skin, photodamage, or people who already use Botox and Filler to try the product for Free in exchange for their before and after pictures and thoughts.   The science behind our peptides and the multiple clinical studies suggested that changes could be seen within 30 days.

25 Real clients, women and men, volunteered to participate in our Skinsurrection GenaViVe trial to test the product for effectiveness. The clients applied one drop of GenaViVe Anti-Wrinkle Anti-Aging serum to a problem area.  Of our 25 participants, most we concerned with crow’s feet (lateral canthal lines), 11 lines (glabellar lines), under eye bags (periorbital puffiness), forehead lines (musical staff lines) or smoker’s lines (vermillion border). We analyzed their result and took in their feedback so that we could optimize our final product.

 Here are some of the results:

GenaViVE Results, Crow's Feet & Under eye bags
GenaViVE Results, Crow’s Feet & Under eye bags.
Volunteer #7
GenaViVE Results, Crow's Feet & Under eye bags
GenaViVE Results, Crow’s Feet & Under eye bags.
GenaViVE Results, Crow's Feet.
GenaViVE Results, Crow’s Feet. Volunteer #19


Four other volunteers were regular Botox users, having it done at least twice yearly.   And all 3 of them have used filler.  All report that they believe the product is improving the results they have and feel like they can wait additional time before having the next Botox and Filler treatment.   This is the result and feedback that we expected based on the reports in the literature about this combination of peptides.

To ORDER GENAVIVE or For more information about GenaViVe Anti-Wrinkle peptide serum, visit our website and follow Skinsurrection on Facebook, Skinsurrection on Instagram, and Skinsurrection on Twitter.

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